Trust me, I'm the Doctor
"There are worlds out there where the sky is burning, where the sea is asleep and the rivers dream; people made of smoke and cities made of song. Somewhere there's danger, somewhere there's injustice, and somewhere else the tea is getting cold. Come on, Ace, we've got work to do."


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2 days ago on September 27th, 2014 | J | 4 notes
Me: Who's a good boy?
Dog: ???????????????????????????????????????????????????????????????????????????????????????????????????????????
Me: YOU'RE A GOOD BOY!
Dog: !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
2 days ago on September 27th, 2014 | J | 346,722 notes
2 days ago on September 27th, 2014 | J | 294,381 notes

lesbolution:

reblog if u remember when apple was a FRUIT, kids played OUTSIDE not on their ipads, and decomposing VICTIMS of the BUBONIC plague LITTERED the STREETS

2 days ago on September 27th, 2014 | J | 351,023 notes

copperbadge:

nanyoky:

I want to write an alternative version of Romeo and Juliet where instead of being a little ponce and trying to work things out for himself, Romeo asks his smarter friends what to do about the whole thing and Benvolio and Mercutio come up with the world’s greatest…

2 days ago on September 27th, 2014 | J | 13,291 notes
2 days ago on September 27th, 2014 | J | 1,033 notes
houseofmind:

The Curious Case of the Woman with No Cerebellum
Not sure how many of you have read about this by now, but it is such an amazing finding I decided to write about it (even though I retweeted this yesterday). 
This study is a clinical case report of a living patient with cerebellar   agenesis, an extremely rare condition characterized by the absence of the cerebellum. The cause is currently unknown, there are limited reported cases of complete cerebellar  agenesis, and most of what we know about the condition comes from autopsy reports instead of living patients. Moreover, the condition is difficult to study because most individuals with complete primary cerebellar agenesis are infants or children with severe mental impairment, epilepsy, hydrocephaly and other gross lesions of the CNS. The fact that this woman is alive and has a somewhat “normal” life is ground-breaking and presents a unique opportunity to study the condition.
The patient described in the study is 24 years old. She has mild mental impairment and moderate motor deficits. For example, she is unable to walk steadily and commonly experiences dizziness/nausea. She also has speech problems and cannot run or jump. However, she has no history of neurological disorders and even gave birth without any complications. 
Importantly, as shown above, CT  and MRI scans revealed no presence of recognizable cerebellar structures. Just look at that dark sport towards the back of the brain! In addition to these findings, magnetic resonance angiography also demonstrated vascular characteristics of this patient consistent with complete cerebellar agenesis- meaning that the arteries that normally supply this area were also absent bilaterally. How crazy is that? Futhermore, diffusion tensor imaging  indicated a complete lack of the efferent and afferent limbs of the cerebellum. 
Given that the cerebellum is responsible for both motor and non-motor functions, these results are pretty amazing. How can the brain compensate for such a heavy blow to its architecture and connectivity? According to the authors of the study: 

This surprising phenomenon supports the concept of extracerebellar motor system plasticity, especially cerebellum loss, occurring early in life. We conclude that the cerebellum is necessary for normal motor, language functional and mental development even in the presence of the functional compensation phenomenon.

Source:
Yu, F., Jiang, Q., Sun, X., and Zhang, R. (2014). A new case of complete primary cerebellar a genesis: clinical and imaging findings in a living patient. Brain. doi: 10.1093/brain/awu239

houseofmind:

The Curious Case of the Woman with No Cerebellum

Not sure how many of you have read about this by now, but it is such an amazing finding I decided to write about it (even though I retweeted this yesterday). 

This study is a clinical case report of a living patient with cerebellar   agenesis, an extremely rare condition characterized by the absence of the cerebellum. The cause is currently unknown, there are limited reported cases of complete cerebellar  agenesis, and most of what we know about the condition comes from autopsy reports instead of living patients. Moreover, the condition is difficult to study because most individuals with complete primary cerebellar agenesis are infants or children with severe mental impairment, epilepsy, hydrocephaly and other gross lesions of the CNS. The fact that this woman is alive and has a somewhat “normal” life is ground-breaking and presents a unique opportunity to study the condition.

The patient described in the study is 24 years old. She has mild mental impairment and moderate motor deficits. For example, she is unable to walk steadily and commonly experiences dizziness/nausea. She also has speech problems and cannot run or jump. However, she has no history of neurological disorders and even gave birth without any complications. 

Importantly, as shown above, CT  and MRI scans revealed no presence of recognizable cerebellar structures. Just look at that dark sport towards the back of the brain! In addition to these findings, magnetic resonance angiography also demonstrated vascular characteristics of this patient consistent with complete cerebellar agenesis- meaning that the arteries that normally supply this area were also absent bilaterally. How crazy is that? Futhermore, diffusion tensor imaging  indicated a complete lack of the efferent and afferent limbs of the cerebellum. 

Given that the cerebellum is responsible for both motor and non-motor functions, these results are pretty amazing. How can the brain compensate for such a heavy blow to its architecture and connectivity? According to the authors of the study: 

This surprising phenomenon supports the concept of extracerebellar motor system plasticity, especially cerebellum loss, occurring early in life. We conclude that the cerebellum is necessary for normal motor, language functional and mental development even in the presence of the functional compensation phenomenon.

Source:

Yu, F., Jiang, Q., Sun, X., and Zhang, R. (2014). A new case of complete primary cerebellar a genesis: clinical and imaging findings in a living patient. Braindoi: 10.1093/brain/awu239

2 days ago on September 27th, 2014 | J | 726 notes
2 days ago on September 27th, 2014 | J | 2,387 notes
prattical:

same

prattical:

same

2 days ago on September 27th, 2014 | J | 46,903 notes

videogamenostalgia:

Jenny LeClue-Detectivú

Not Nancy Drew, but Jenny LeClue, a new face in the choose-your-own story mystery adventure scene. This is to be a trilogy mystery game series with a rich, involving story and plenty of mystery to satiate your curiosities. The kickstarter has been fully funded however there’s almost two days left to pledge in and get your rewards! With the game Greenlit on Steam as well, the team is set to go and plans on releasing an alpha by Spring 2015. There’s a lot to be discovered in this charming adventure that we look forward to by the beginning of next year!

2 days ago on September 27th, 2014 | J | 3,640 notes
2 days ago on September 27th, 2014 | J | 7,705 notes

cleowho:

"Ah, don’t be so pessimistic."

Time Heist - series 08 - 2014

6 days ago on September 24th, 2014 | J | 553 notes
6 days ago on September 24th, 2014 | J | 10 notes

benmorrisillustration:

Infographic for ‘Who-ology’, BBC Books 2013.

6 days ago on September 24th, 2014 | J | 8 notes
benmorrisillustration:

The Doctor’s Family Tree, Who-ology, BBC Books 2013.

benmorrisillustration:

The Doctor’s Family Tree, Who-ology, BBC Books 2013.

6 days ago on September 24th, 2014 | J | 22 notes